Serendipity strikes twice: the discovery and rediscovery of defective ribosomal products (DRiPS)
- PMID: 16359615
Serendipity strikes twice: the discovery and rediscovery of defective ribosomal products (DRiPS)
Abstract
Here I recount how the remarkably large fraction of rapidly degraded nascent proteins was discovered through serendipity not once, but twice. This story is used as a canvas for discussing how the imperfections in human nature retard scientific progress.
Similar articles
-
Quantitating defective ribosome products.Methods Mol Biol. 2005;301:271-81. doi: 10.1385/1-59259-895-1:271. Methods Mol Biol. 2005. PMID: 15917638
-
Autophagy inhibition promotes defective neosynthesized proteins storage in ALIS, and induces redirection toward proteasome processing and MHCI-restricted presentation.Autophagy. 2012 Mar;8(3):350-63. doi: 10.4161/auto.18806. Epub 2012 Mar 1. Autophagy. 2012. PMID: 22377621
-
A fatal affair: the ubiquitinylation of proteins.Angew Chem Int Ed Engl. 2004 Dec 3;43(47):6414-6. doi: 10.1002/anie.200462346. Angew Chem Int Ed Engl. 2004. PMID: 15578782 Review. No abstract available.
-
Ubiquitin at Fox Chase.Cell Death Differ. 2005 Sep;12(9):1198-201. doi: 10.1038/sj.cdd.4401710. Cell Death Differ. 2005. PMID: 16094396 Review.
-
Tracing the history of the ubiquitin proteolytic system: the pioneering article.Biochem Biophys Res Commun. 2009 Sep 11;387(1):1-10. doi: 10.1016/j.bbrc.2009.06.065. Epub 2009 Jun 17. Biochem Biophys Res Commun. 2009. PMID: 19539608
Cited by
-
Branching in the sequential folding pathway of cytochrome c.Protein Sci. 2007 Sep;16(9):1946-56. doi: 10.1110/ps.072922307. Epub 2007 Jul 27. Protein Sci. 2007. PMID: 17660254 Free PMC article.
-
How is the balance between protein synthesis and degradation achieved?Theor Biol Med Model. 2010 Jun 23;7:25. doi: 10.1186/1742-4682-7-25. Theor Biol Med Model. 2010. PMID: 20573219 Free PMC article.
-
Influence of translation efficiency of homologous viral proteins on the endogenous presentation of CD8+ T cell epitopes.J Exp Med. 2007 Mar 19;204(3):525-32. doi: 10.1084/jem.20062508. Epub 2007 Feb 20. J Exp Med. 2007. PMID: 17312009 Free PMC article.
-
Proteasome dynamics in response to metabolic changes.Front Cell Dev Biol. 2025 Mar 3;13:1523382. doi: 10.3389/fcell.2025.1523382. eCollection 2025. Front Cell Dev Biol. 2025. PMID: 40099196 Free PMC article. Review.
-
The Best for the Most Important: Maintaining a Pristine Proteome in Stem and Progenitor Cells.Stem Cells Int. 2019 May 2;2019:1608787. doi: 10.1155/2019/1608787. eCollection 2019. Stem Cells Int. 2019. PMID: 31191665 Free PMC article. Review.