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doi: 10.1016/j.cell.2005.11.025.
PIDD: a switch hitter
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- PMID: 16360026
- DOI: 10.1016/j.cell.2005.11.025
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PIDD: a switch hitter
Cell.
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Abstract
In response to genotoxic stress, the PIDD protein promotes apoptosis downstream of the tumor-suppressor protein p53. In this issue of Cell, Janssens et al. (2005) demonstrate that, in response to such stress, PIDD forms a nuclear complex that enhances sumoylation of NEMO. This modification is important for the activation of the antiapoptotic transcription factor NF-kappaB.
Comment on
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PIDD mediates NF-kappaB activation in response to DNA damage.Cell. 2005 Dec 16;123(6):1079-92. doi: 10.1016/j.cell.2005.09.036. Cell. 2005. PMID: 16360037
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