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Comment
. 2005 Dec 16;123(6):980-2.
doi: 10.1016/j.cell.2005.11.025.

PIDD: a switch hitter

Zhao-Hui Wu  1 , Angela Mabb, Shigeki Miyamoto
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PIDD: a switch hitter

Zhao-Hui Wu et al. Cell. .
Free article

Abstract

In response to genotoxic stress, the PIDD protein promotes apoptosis downstream of the tumor-suppressor protein p53. In this issue of Cell, Janssens et al. (2005) demonstrate that, in response to such stress, PIDD forms a nuclear complex that enhances sumoylation of NEMO. This modification is important for the activation of the antiapoptotic transcription factor NF-kappaB.

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