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Comment
. 2005 Dec 16;123(6):985-7.
doi: 10.1016/j.cell.2005.11.029.

Under pressure: stromal fibroblasts change their ways

Brian Bierie  1 , Harold L Moses
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Under pressure: stromal fibroblasts change their ways

Brian Bierie et al. Cell. .
Free article

Abstract

In this issue of Cell, Hill et al. (2005) demonstrate in a mouse model of prostate cancer that the tumor cells can initiate and promote expansion of stromal fibroblasts that lack the tumor-suppressor protein p53 through a paracrine mechanism. This results in selection of highly proliferative fibroblasts associated with the carcinoma that further promote tumor progression.

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