Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Feb;78(2):159-64.
doi: 10.1016/j.radonc.2005.11.010. Epub 2005 Dec 15.

Evaluation of underdosage in the external photon beam radiotherapy of glottic carcinoma: Monte Carlo study

Siarhei Spirydovich  1 , Lech Papiez, Vadim Moskvin, Paul Desrosiers
Affiliations

Evaluation of underdosage in the external photon beam radiotherapy of glottic carcinoma: Monte Carlo study

Siarhei Spirydovich et al. Radiother Oncol. 2006 Feb.

Abstract

Purpose: Underdosage in the human larynx may be the true factor behind the decrease in local control rates.

Patients and methods: To evaluate underdosage with Monte Carlo a CT-based geometrical model of the patient's neck (mathematical neck) was created. Dose was calculated for a pair of 6 Me V parallel-opposed photon beams modulated with 15 degree steel wedges.

Results: At least 5% of volume of 3.5 cm(3) hypothetical tumor near the air wall of the larynx receives less than 86% of the maximum tumor dose. The same volume received less than 91% of the maximum tumor dose when the mathematical neck had no air cavities.

Conclusions: We conclude the significant underdosage at the air-tissue interface in the larynx occurs in traditional radiotherapy treatments, especially in the glottic part of the larynx.

PubMed Disclaimer

LinkOut - more resources