Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Jan;90(1):103-8.
doi: 10.1136/bjo.2005.072686.

Toll-like receptors in ocular immunity and the immunopathogenesis of inflammatory eye disease

J H Chang  1 , P J McCluskey, D Wakefield
Affiliations
Review

Toll-like receptors in ocular immunity and the immunopathogenesis of inflammatory eye disease

J H Chang et al. Br J Ophthalmol. 2006 Jan.

Abstract

Microbial agents have an important role in the pathogenesis of various inflammatory eye diseases, such as uveitis and keratitis. Microbial infections of the eye such as microbial keratitis, ocular onchocerciasis, bacterial endophthalmitis, viral retinitis, and other infectious uveitis are unfortunately common. In addition, microbial agents have been implicated in the pathogenesis of "non-infectious" immune mediated diseases such as HLA-B27 associated acute anterior uveitis. Toll-like receptors (TLR) are a family of pattern recognition receptors that initiates rapid host innate immune response to microbial components known as pathogen associated molecular patterns, which are unique to a given class of microbes, such as lipopolysaccharide of Gram negative bacteria. Recent in vitro and in vivo studies have demonstrated the expression and function of TLRs in the eye, with significant implications for better understanding of ocular immunity and the pathogenesis of inflammatory eye diseases affecting the cornea, uvea, and retina.

PubMed Disclaimer

Conflict of interest statement

The authors have no competing interests regarding any aspects of this work.

References

    1. Streilein J W, Stein‐Streilein J. Does innate immune privilege exist? J Leukoc Biol 200067479–487. - PubMed
    1. Chang J H, McCluskey P J, Wakefield D. Acute anterior uveitis and HLA‐B27. Surv Ophthalmol 200550364–388. - PubMed
    1. Iwasaki A, Medzhitov R. Toll‐like receptor control of the adaptive immune responses. Nat Immunol 20045987–995. - PubMed
    1. Takeda K, Akira S. Toll‐like receptors in innate immunity. Int Immunol 2005171–14. - PubMed
    1. Takeda K, Kaisho T, Akira S. Toll‐like receptors. Annu Rev Immunol 200321335–376. - PubMed

Publication types

Substances