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. 2006 Jan 15;193(2):283-6.
doi: 10.1086/498875. Epub 2005 Dec 2.

Lack of association between infection with a novel human coronavirus (HCoV), HCoV-NH, and Kawasaki disease in Taiwan

Luan-Yin Chang  1 , Bor-Luen Chiang, Chuan-Liang Kao, Mei-Hwan Wu, Pei-Jer Chen, Ben Berkhout, Hui-Ching Yang, Li-Min Huang; Kawasaki Disease Research Group
Affiliations

Lack of association between infection with a novel human coronavirus (HCoV), HCoV-NH, and Kawasaki disease in Taiwan

Luan-Yin Chang et al. J Infect Dis. .

Abstract

We investigated whether infection with a novel human coronavirus (HCoV), called "New Haven coronavirus" (HCoV-NH)--which is similar to and likely represents the same species as another novel HCoV, HCoV-NL63--is associated with Kawasaki disease (KD) in Taiwan. Fifty-three patients with KD were enrolled in our study. Serum, peripheral-blood mononuclear cells, nasopharyngeal aspirates, throat swabs, and rectal swabs from these patients were assayed for HCoV-NL63 by real-time reverse-transcriptase (RT) polymerase chain reaction (PCR), and the throat swabs, nasopharyngeal aspirates, and rectal swabs were also assayed for HCoV-NH by RT-PCR. All PCR results were negative for both HCoV-NL63 and HCoV-NH; therefore, we did not find any association between HCoV-NH infection and KD in Taiwan.

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Conflict of interest statement

Potential conflicts of interest: none reported

Figures

Table 1
Table 1
Clinical manifestations in 53 patients with Kawasaki disease
Table 2
Table 2
Sample sizes of different kinds of specimens assayed for human coronavirus (HCoV)–NL63 by real-time reverse-transcriptase (RT) polymerase chain reaction (PCR) and for HCoV-NH by RT-PCR
See this image and copyright information in PMC

References

    1. Kawasaki T. Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children [in Japanese] Arerugi. 1967;16:178–222. - PubMed
    1. Chang LY, Chang IS, Lu CY, et al. Epidemiological features of Kawasaki disease in Taiwan from 1996 to 2002. Pediatrics. 2004;114:e678–82. - PubMed
    1. Yanagawa H, Yashiro M, Nakamura Y, et al. Epidemiologic pictures of Kawasaki disease in Japan: from the nationwide incidence survey in 1991 and 1992. Pediatrics. 1995;95:475–9. - PubMed
    1. Holman RC, Curns AT, Belay ED, Steiner CA, Schonberger LB. Kawasaki syndrome hospitalizations in the United States, 1997 and 2000. Pediatrics. 2003;112:495–501. - PubMed
    1. Holman RC, Curns AT, Belay ED, et al. Kawasaki syndrome in Hawaii. Pediatr Infect Dis J. 2005;24:429–33. - PubMed

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