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Review
. 2006 Apr;27(5):501-17.
doi: 10.1016/j.ejps.2005.11.002. Epub 2005 Dec 20.

The role of transporters in drug interactions

Christopher J Endres  1 , Peng Hsiao, Francisco S Chung, Jashvant D Unadkat
Affiliations
Review

The role of transporters in drug interactions

Christopher J Endres et al. Eur J Pharm Sci. 2006 Apr.

Abstract

Transport proteins play an important role in the adsorption, distribution and elimination of a wide variety of drugs. Therefore, it is not surprising that transporter-based drug interactions can occur in the clinic. These interactions can lead to changes in toxicity and/or efficacy of the affected drug. Here, we review such interactions and ask if these interactions could have been predicted from in vitro data. Conducting such in vitro-in vivo correlation is important for predicting future transporter-based drug interactions.

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