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Review
. 2005 Dec 22;48(6):873-5.
doi: 10.1016/j.neuron.2005.12.005.

To think or not to think: synaptic activity and Abeta release

Brock E Schroeder  1 , Edward H Koo
Affiliations
Free article
Review

To think or not to think: synaptic activity and Abeta release

Brock E Schroeder et al. Neuron. .
Free article

Abstract

Accumulation of beta-amyloid protein (Abeta) in the extracellular space of the brain has been hypothesized to be a culprit in the pathogenesis of Alzheimer's disease. In this issue of Neuron, Cirrito et al. describe a series of experiments demonstrating that extracellular Abeta levels are directly modulated by neuronal and synaptic activity.

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