doi: 10.1021/ja056463s.
Allosteric control of oligonucleotide hybridization by metal-induced cyclization
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- PMID: 16366548
- DOI: 10.1021/ja056463s
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Allosteric control of oligonucleotide hybridization by metal-induced cyclization
J Am Chem Soc.
.
Abstract
A bis(terpyridine) modified single-stranded DNA smoothly forms a stable cycle by Fe2+-assisted ring closure. A novel, complex type of allosteric behavior is observed with Zn2+, which reversibly off-regulates binding of a complementary oligonucleotide only in a narrow concentration range.
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