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. 2005 Dec 28;127(51):18016-7.
doi: 10.1021/ja056463s.

Allosteric control of oligonucleotide hybridization by metal-induced cyclization

Mareike Göritz  1 , Roland Krämer
Affiliations

Allosteric control of oligonucleotide hybridization by metal-induced cyclization

Mareike Göritz et al. J Am Chem Soc. .

Abstract

A bis(terpyridine) modified single-stranded DNA smoothly forms a stable cycle by Fe2+-assisted ring closure. A novel, complex type of allosteric behavior is observed with Zn2+, which reversibly off-regulates binding of a complementary oligonucleotide only in a narrow concentration range.

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