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. 2005 Dec 28;127(51):18020-1.
doi: 10.1021/ja056800x.

A solution to the 2-pyridyl organometallic cross-coupling problem: regioselective catalytic direct arylation of pyridine N-oxides

Louis-Charles Campeau  1 , Sophie Rousseaux, Keith Fagnou
Affiliations

A solution to the 2-pyridyl organometallic cross-coupling problem: regioselective catalytic direct arylation of pyridine N-oxides

Louis-Charles Campeau et al. J Am Chem Soc. .

Abstract

Direct arylation reactions of pyridine N-oxides occur in excellent yield with complete selectivity for the 2-position with a wide range of aryl bromides. This reactivity permits the use of inexpensive, commercially available, and bench-stable pyridine N-oxides as replacements for problematic 2-metallapyridines in palladium-catalyzed cross-coupling reactions.

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