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. 2006 Apr;38(4):540-6.
doi: 10.1016/j.bone.2005.10.019. Epub 2005 Dec 20.

The effects of local platelet rich plasma delivery on diabetic fracture healing

Ankur Gandhi  1 , Christopher Doumas, J Patrick O'Connor, J Russell Parsons, Sheldon S Lin
Affiliations

The effects of local platelet rich plasma delivery on diabetic fracture healing

Ankur Gandhi et al. Bone. 2006 Apr.

Erratum in

  • Bone. 2006 Jun;38(6):957

Abstract

Several studies have documented that diabetes impairs bone healing clinically and experimentally. The percutaneous delivery of platelet rich plasma (PRP) was used in the diabetic BB Wistar femur fracture model to investigate the use of PRP as a concentrated source of critical early growth factors on bone healing. PRP delivery at the fracture site normalized the early (cellular proliferation and chondrogenesis) parameters while improving the late (mechanical strength) parameters of diabetic fracture healing. These results suggest a role for PRP in mediating diabetic fracture healing and potentially other high risk fractures.

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