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Clinical Trial
. 2005 Jun 16;7(2):2.

Serum antibodies to oral anaerobic bacteria in patients with rheumatoid arthritis

Mesut Ogrendik  1 , Siranus Kokino, Ferda Ozdemir, Philip S Bird, Stephen Hamlet
Affiliations
Clinical Trial

Serum antibodies to oral anaerobic bacteria in patients with rheumatoid arthritis

Mesut Ogrendik et al. MedGenMed. .

Abstract

Background: This study was conducted to determine the component that causes the disease in rheumatoid arthritis (RA), which shows great resemblance to periodontitis in a pathologic context.

Materials and methods: Within this study, the pathogen-specific IgG levels formed against Porphyromonas gingivalis FDC 381, Prevotella melaninogenica ATCC 25845, Actinobacillus actinomycetemcomitans Y4, Bacteroides forsythus ATCC 43047, and Prevotella intermedia 25611 oral bacteria were researched from the blood serum samples of 30 RA patients and 20 healthy controls with the enzyme-linked immunosorbent assay (ELISA) method.

Results: The IgG levels of P gingivalis, P intermedia, P melaninogenica, and B forsythus were found to be significantly higher in RA patients when compared with those of the controls. Of the other bacteria antibodies, A actinomycetemcomitans was not found at greater levels in RA serum samples in comparison with the healthy samples.

Conclusion: The antibodies formed against P gingivalis, P intermedia, P melaninogenica, and B forsythus could be important to the etiopathogenesis of RA.

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Figures

Figure 1
Figure 1
Poryphyromonas gingivalis and serum C-reactive protein detected in patients with rheumatoid arthritis.
Figure 2
Figure 2
Correlation between serum immunoglobulin (Ig)G antibody levels against Prevotella intermedia and erythrocyte sedimentation rate.
See this image and copyright information in PMC

References

    1. Albani S, Carson DA. Etiology and pathogenesis of rheumatoid arthritis. In: Koopman WJ, editor. Arthritis and allied conditions. Baltimore: Williams and Wilkins; 1997. pp. 979–992.
    1. Mercado FB, Marshall RI, Klestov AC, Bartold PM. Relationship between rheumatoid arthritis and periodontitis. J Periodontol. 2001;72:779–787. - PubMed
    1. Greenwald RA, Kirkwood K. Adult periodontitis as a model for rheumatoid arthritis (with emphasis on treatment strategies) J Rheumatol. 1999;26:1650–1653. - PubMed
    1. Katz J, Goultschin J, Benoliel R, Brautbar C. Human leukocyte antigen (HLA) DR4. Positive association with rapidly progressing periodontitis. J Periodontol. 1987;58:607–610. - PubMed
    1. Gran JT, Husby G, Thorsby E. The association between rheumatoid arthritis and HLA antigen DR4. Ann Rheum Dis. 1983;42:292–296. - PMC - PubMed

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