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Review
. 2005 Nov;8(3-4):221-5.
doi: 10.1007/BF03033975.

Role of astrocytes in glutamate homeostasis: implications for excitotoxicity

Arne Schousboe  1 , Helle S Waagepetersen
Affiliations
Review

Role of astrocytes in glutamate homeostasis: implications for excitotoxicity

Arne Schousboe et al. Neurotox Res. 2005 Nov.

Abstract

Glutamate homeostasis in the brain is maintained by its well balanced release, uptake and metabolism. It appears that astrocytes play a prominent role in this context since they possess a very powerful battery of glutamate transporters. Thus, malfunction of astrocytic glutamate transporters will lead to an excessively high extracellular glutamate concentration which may result in neurodegeneration caused by the excitotoxic action of glutamate.

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References

    1. Neuron. 1995 May;14(5):1019-27 - PubMed
    1. Prog Neurobiol. 1990;35(4):245-96 - PubMed
    1. Brain Res. 2000 Jun 16;868(1):105-12 - PubMed
    1. J Neurosci Res. 2001 Dec 1;66(5):909-13 - PubMed
    1. Neurochem Res. 1978 Feb;3(1):1-14 - PubMed

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