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. 2006 Jan;91(1):F65-6.
doi: 10.1136/adc.2005.074245.

Umbilical cord blood procalcitonin and C reactive protein concentrations as markers for early diagnosis of very early onset neonatal infection

N Joram  1 , C Boscher, S Denizot, V Loubersac, N Winer, J C Roze, C Gras-Le Guen
Affiliations

Umbilical cord blood procalcitonin and C reactive protein concentrations as markers for early diagnosis of very early onset neonatal infection

N Joram et al. Arch Dis Child Fetal Neonatal Ed. 2006 Jan.

Abstract

Procalcitonin (PCT) and C reactive protein (CRP) concentrations in umbilical cord blood of 197 neonates were measured to evaluate their value as markers of infection. Sixteen of the neonates were infected. The sensitivity, specificity, and negative and positive predictive values were respectively 87.5%, 98.7%, 87.5%, and 98.7% for PCT and 50%, 97%, 67%, and 94% for CRP. Serum PCT in cord blood seems to be a useful and early marker of antenatal infection.

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Conflict of interest statement

Competing interests: none declared

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References

    1. Gendrel D, Assicot M, Raymond J.et al Procalcitonin as a marker for the early diagnosis of neonatal infection. J Pediatr 1996128570–573. - PubMed
    1. Chiesa C, Panero A, Rossi N A.et al Reliability of procalcitonin concentrations for the diagnosis of sepsis in critically ill neonates. Clin Infect Dis 199826664–672. - PubMed
    1. Sachse C, Dressler F, Henkel E. Increased serum procalcitonin in newborn infants without infection. Clin Chem 1998441343–1344. - PubMed
    1. Mathers N J, Pohlandt F. Diagnostic audit of C‐reactive protein in neonatal infection. Eur J Pediatr 1987146147–151. - PubMed
    1. Lapillonne A, Basson E, Monneret G.et al Lack of specificity of procalcitonin for sepsis diagnosis in premature infants. Lancet 19983511211–1212. - PubMed

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