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. 2006 Jan;8(1):61-7.
doi: 10.1111/j.1745-7262.2006.00069.x.

A differentially methylated region of the DAZ1 gene in spermatic and somatic cells

Zuo-Xiang Li  1 , Xu Ma, Zhao-Hui Wang
Affiliations
Free article

A differentially methylated region of the DAZ1 gene in spermatic and somatic cells

Zuo-Xiang Li et al. Asian J Androl. 2006 Jan.
Free article

Abstract

Aim: To investigate the methylation status of the deleted in azoospermia 1 (DAZ1) gene promoter region in different cell types.

Methods: Using CpG island Searcher software, a CpG island was found in the promoter region of the DAZ1 gene. The methylation status of this region was analyzed in sperm and leukocytes by bisulfited sequencing.

Results: The methylation status of the CpG island in the DAZ1 gene promoter region differed in leukocytes and sperm: it was methylated in leukocytes, but unmethylated in sperm.

Conclusion: A differentially methylated region of the DAZ1 gene exists in spermatic and somatic cells, suggesting that methylation of this region may regulate DAZ1 gene expression in different tissues.

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