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. 2005 Dec;17(8):646-9.
doi: 10.1016/j.clon.2005.06.009.

Intravenous irinotecan plus oral ciclosporin

N S Vasudev  1 , S Jagdev, D A Anthoney, M T Seymour
Affiliations

Intravenous irinotecan plus oral ciclosporin

N S Vasudev et al. Clin Oncol (R Coll Radiol). 2005 Dec.

Abstract

We previously reported a phase I study of intravenous irinotecan plus oral ciclosporin, in which dose-limiting diarrhoea was not observed, supporting the hypothesis that pharmacokinetic modulation of irinotecan by ciclosporin may improve its therapeutic index. We now report results of a further 34 patients treated at the recommended dose. A low rate of diarrhoea of grade 3 or above (3%) was again seen, with useful anti-tumour activity. The regimen is to be formally evaluated as part of a future phase III trial.

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