Comparative efficacy of aceclofenac and etoricoxib in post extraction pain control: randomized control trial

Abstract

The study is a prospective randomized double blind clinical trial comparing the efficacy of nonselective NSAIDs (Aceclofenac) and highly selective COX-2 inhibitors (Etoricoxib) in post extraction pain control. The primary efficacy was judged by overall assessment of onset and duration of analgesic effect and rate of decrease in pain intensity by a visual analogue scale over a 3-day investigation period. 100 patients were enrolled in the study (50 patients in aceclofenac group and 50 patients in etoricoxib group). Twice-daily dosage of aceclofenac 100 mg and etoricoxib 60 mg were recommended for the double blind study. 64 patients completed the study. Efficacy of pain control over baseline data documented in both the treatment groups were statistically significant (p<0.05). There was no significant difference between the two drugs.