Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2005 Jul:23 Suppl 2:5-24.
doi: 10.1016/S0213-005X(05)75156-9.

Current situation in the development of a preventive HIV vaccine

[Article in English, Spanish]
José Alcamí  1 , Joan Joseph Munné, María Angeles Muñoz-Fernández, Mariano Esteban
Affiliations
Review

Current situation in the development of a preventive HIV vaccine

[Article in English, Spanish]
José Alcamí et al. Enferm Infecc Microbiol Clin. 2005 Jul.

Abstract

The uncontrolled progression of the AIDS epidemic has made the development of an efficacious human immunodeficiency virus (HIV) vaccine a major objective of scientific research. No effective preventive vaccine against HIV is currently available and sterilizing immunity has not yet been achieved in animal models. This review analyses the major challenges in developing an AIDS vaccine, in particular the mechanisms involved in viral escape from the immune response, and summarizes the results obtained with the different prototypes of therapeutic and preventive vaccines. Finally, social, economic and healthcare aspects of research into HIV vaccines and current controversies regarding the development of clinical trials are discussed.

PubMed Disclaimer

References

    1. WHO . WHO; Genève: 2003. UNAIDS report on the global HIV/AIDS epidemic.
    1. Nossal G.J.V. The global alliance for vaccines and immunization: a millennial challenge. Nature Immunol. 2000;1:1–7. - PubMed
    1. Esparza J., Bhamarapravati N. Accelerating the development and future availability of HIV-1 vaccines: why, when, where, and how? Lancet. 2000;355:2061–2066. - PubMed
    1. Nabel G.J. Challenges and opportunities for development of an AIDS vaccines. Nature. 2001;410:1002–1006. - PubMed
    1. McMichael A., Hanke T. HIV vaccines 1983-2003. Nat Med. 2003;9:874–880. - PubMed

Publication types

MeSH terms

LinkOut - more resources