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. 2006 May;21(5):1316-9.
doi: 10.1093/humrep/dei457. Epub 2005 Dec 22.

A cross-sectional study of the forearm bone density of long-term users of levonorgestrel-releasing intrauterine system

Luis Bahamondes  1 , Ximena Espejo-Arce, Maria M Hidalgo, Creusa Hidalgo-Regina, Cássia Teatin-Juliato, Carlos A Petta
Affiliations

A cross-sectional study of the forearm bone density of long-term users of levonorgestrel-releasing intrauterine system

Luis Bahamondes et al. Hum Reprod. 2006 May.

Abstract

Background: There are concerns about the effect of hormonal contraceptives on bone mineral density (BMD), but there is currently no information available on the effect of the levonorgestrel-releasing intrauterine system (LNG-IUS) on BMD. The objective of this study was to compare the BMD of LNG-IUS users with that of controls using the TCu380A intrauterine device (IUD).

Materials and methods: A cross-sectional study paired 53 women, aged 25-51 years, who had been using the LNG-IUS for 7 years, with 53 IUD users, according to age (+/-1 year) and body mass index (BMI; kg/m2) (+/-1). BMD was evaluated at the midshaft of the ulna and the distal radius of the nondominant forearm using double X-ray absorptiometry.

Results: Mean age of women was 34 years. BMI was slightly over 25 in both groups. Estradiol was normal. Mean BMD was 0.469 +/- 0.008 and 0.467 +/- 0.009 and 0.409 +/- 0.009 and 0.411 +/- 0.009 at the midshaft of the ulna and distal radius in LNG-IUS and IUD users, respectively, without significant differences.

Conclusions: Women aged 25-51 years, using the LNG-IUS for 7 years, had a mean BMD similar to that of the control group of TCu380A IUD users.

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