Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Dec 23;310(5756):1966-70.
doi: 10.1126/science.1119407.

Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2

Sangwon F Kim  1 , Daniel A Huri, Solomon H Snyder
Affiliations

Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2

Sangwon F Kim et al. Science. .

Abstract

Cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Here we show that iNOS specifically binds to COX-2 and S-nitrosylates it, enhancing COX-2 catalytic activity. Selectively disrupting iNOS-COX-2 binding prevented NO-mediated activation of COX-2. This synergistic molecular interaction between two inflammatory systems may inform the development of anti-inflammatory drugs.

PubMed Disclaimer

Publication types