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. 2006 Jan;43(1):51-3.
doi: 10.1002/hep.20998.

Nasobiliary drainage induces long-lasting remission in benign recurrent intrahepatic cholestasis

Janneke M Stapelbroek  1 , Karel J van Erpecum, Leo W J Klomp, Niels G Venneman, Thijs P Schwartz, Gerard P van Berge Henegouwen, John Devlin, Carin M J van Nieuwkerk, A S Knisely, Roderick H J Houwen
Affiliations

Nasobiliary drainage induces long-lasting remission in benign recurrent intrahepatic cholestasis

Janneke M Stapelbroek et al. Hepatology. 2006 Jan.

Abstract

Benign recurrent intrahepatic cholestasis (BRIC) is characterized by episodic cholestasis and pruritus without anatomical obstruction. Effective medical treatment is not available. We report complete and long-lasting disappearance of pruritus and normalization of serum bile salt concentrations in cholestatic BRIC patients within 24 hours after endoscopic nasobiliary drainage (NBD). Relative amounts of phospholipids and bile salts in bile collected during NBD appeared to be normal, but phospholipids other than phosphatidylcholine (especially sphingomyelin) were increased. In conclusion, we propose that temporary endoscopic nasobiliary drainage should be considered in cholestatic BRIC patients.

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