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Review
. 2005 Dec 29;123(7):1178-9.
doi: 10.1016/j.cell.2005.12.004.

Gene regulation by histone H1: new links to DNA methylation

Ralph A W Rupp  1 , Peter B Becker
Affiliations
Free article
Review

Gene regulation by histone H1: new links to DNA methylation

Ralph A W Rupp et al. Cell. .
Free article

Abstract

Linker histones of the H1 family are among the most abundant components of chromatin. In this issue of Cell, the effect of H1 downregulation on gene expression is examined. Although a 50% reduction of histone H1 levels in embryonic stem cells affects chromatin structure globally, the expression of very few genes is altered. Intriguingly, this study reveals a new link between H1 and DNA methylation.

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