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. 2006 Jan;50(1):344-7.
doi: 10.1128/AAC.50.1.344-347.2006.

5-Nitroimidazole drugs effective against metronidazole-resistant Trichomonas vaginalis and Giardia duodenalis

Jacqueline A Upcroft  1 , Linda A Dunn, Janelle M Wright, Kamel Benakli, Peter Upcroft, Patrice Vanelle
Affiliations

5-Nitroimidazole drugs effective against metronidazole-resistant Trichomonas vaginalis and Giardia duodenalis

Jacqueline A Upcroft et al. Antimicrob Agents Chemother. 2006 Jan.

Abstract

Metronidazole (Mz)-resistant Giardia and Trichomonas were inhibited by 1 of 30 new 5-nitroimidazole drugs. Another five drugs were effective against some but not all of the Mz-resistant parasites. This study provides the incentive for the continued design of 5-nitroimidazole drugs to bypass cross-resistance among established 5-nitromidazole antiparasitic drugs.

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Figures

FIG. 1.
FIG. 1.
Structures of the 5-nitroimidazole drugs used in this study compared with that of Mz. MW, molecular weight.
See this image and copyright information in PMC

References

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