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. 2005 Dec;68(12):1782-4.
doi: 10.1021/np0502645.

Antimycobacterial scalarane-based sesterterpenes from the Red Sea sponge Hyrtios erecta

Diaa T A Youssef  1 , Lamiaa A Shaala, Samy Emara
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Antimycobacterial scalarane-based sesterterpenes from the Red Sea sponge Hyrtios erecta

Diaa T A Youssef et al. J Nat Prod. 2005 Dec.

Erratum in

  • J Nat Prod. 2006 Jan;69(1):172

Abstract

A new scalarane-type pentacyclic sesterterpene, sesterstatin 7 (1), was isolated from the Red Sea sponge Hyrtios erecta, together with 16-epi-scalarolbutenolide (2), 25-dehydroxy-12-epi-deacetylscalarin (3), 3-acetylsesterstatin 1 (4), and 21-acetoxydeoxyscalarin. The structure of 1 was elucidated by spectroscopic data interpretation. Sesterstatin 7 (1) showed 63% inhibition of Mycobacterium tuberculosis (H(37)Rv) at a concentration of 6.25 microg/mL. Compound 2 displayed moderate inhibitory activity, while 3 and 4 were weakly active against the same biological target.

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