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Review
. 1992 Apr;74(4):357-62.
doi: 10.1016/0300-9084(92)90113-s.

Recognition of correct reading frame by the ribosome

E N Trifonov  1
Affiliations
Review

Recognition of correct reading frame by the ribosome

E N Trifonov. Biochimie. 1992 Apr.

Abstract

The translation frame-monitoring mechanism has been suggested earlier, based on transient complementary contacts, between mRNA and rRNA. Recent studies related to the frame-monitoring mechanism are reviewed. The mechanism is well supported by both new experimental and sequence analysis data. Experiments are suggested for further elucidation of the structural details of the mRNA-rRNA interaction in the ribosome.

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