Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007 Jan;28(1):18.e1-4.
doi: 10.1016/j.neurobiolaging.2005.11.005. Epub 2005 Dec 27.

The LDLR locus in Alzheimer's disease: a family-based study and meta-analysis of case-control data

Lars Bertram  1 , Monica Hsiao, Matthew B McQueen, Michele Parkinson, Kristina Mullin, Deborah Blacker, Rudolph E Tanzi
Affiliations
Review

The LDLR locus in Alzheimer's disease: a family-based study and meta-analysis of case-control data

Lars Bertram et al. Neurobiol Aging. 2007 Jan.

Abstract

Genetic linkage studies suggest the presence of an Alzheimer's disease (AD) risk gene on chromosome 19, acting independently of apolipoprotein E (apoE), a known AD risk factor on 19q13. The low density lipoprotein receptor (LDLR) is an interesting candidate because it maps within the linked interval, and is intimately involved in cholesterol homeostasis and the function of apoE. We tested three previously reported single nucleotide polymorphisms (SNPs) within LDLR in a large sample of discordant sibships from multiplex AD families, and failed to find evidence for genetic association with disease risk. In addition, we performed meta-analyses for SNP rs5925 on published data from five independent case control samples, but did not detect any significant summary odds ratios. Based on our data, it seems unlikely that these genetic variants in LDLR make a significant contribution to AD risk in the general population.

PubMed Disclaimer

Substances

LinkOut - more resources