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. 2006 Jan 30;146(1):43-51.
doi: 10.1016/j.pscychresns.2005.09.007. Epub 2005 Dec 27.

Does amygdalar perfusion correlate with antidepressant response to partial sleep deprivation in major depression?

Camellia P Clark  1 , Gregory G Brown, Sarah L Archibald, Christine Fennema-Notestine, Deborah R Braun, Linda S Thomas, Ashley N Sutherland, J Christian Gillin
Affiliations

Does amygdalar perfusion correlate with antidepressant response to partial sleep deprivation in major depression?

Camellia P Clark et al. Psychiatry Res. .

Abstract

This study used functional MRI (fMRI) to clarify the sites of brain activity associated with the antidepressant effects of sleep deprivation (SD). We hypothesized: (1) baseline perfusion in right and left amygdalae will be greater in responders than in nonresponders; (2) following partial sleep deprivation (PSD), perfusion in responders' right and left amygdalae would decrease. Seventeen unmedicated outpatients with current major depression and eight controls received perfusion-weighted fMRI and structural MRI at baseline and following 1 night of late-night PSD. Baseline bilateral amygdalar perfusion was greater in responders than nonresponders. Clusters involving both amygdalae decreased from baseline to PSD specifically in responders. Right amygdalar perfusion diverged with PSD, increasing in nonresponders and decreasing in responders. These novel amygdalar findings are consistent with the overarousal hypothesis of SD as well as other functional imaging studies showing increased baseline amygdalar activity in depression and decreased amygdalar activity with remission or antidepressant medications.

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Figures

Fig. 1
Fig. 1
Hand-traced amygdala masks superimposed on the subject’s AC-PC aligned segmented gray matter mask.
Fig. 2
Fig. 2
Areas including amygdalae in which responders’ perfusion decreased from baseline to sleep-deprived scans.
See this image and copyright information in PMC

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