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Review
. 2006 Feb;96(2):252-61.
doi: 10.2105/AJPH.2004.045260. Epub 2005 Dec 27.

The role of vitamin D in cancer prevention

Cedric F Garland  1 , Frank C Garland, Edward D Gorham, Martin Lipkin, Harold Newmark, Sharif B Mohr, Michael F Holick
Affiliations
Review

The role of vitamin D in cancer prevention

Cedric F Garland et al. Am J Public Health. 2006 Feb.

Abstract

Vitamin D status differs by latitude and race, with residents of the northeastern United States and individuals with more skin pigmentation being at increased risk of deficiency. A PubMed database search yielded 63 observational studies of vitamin D status in relation to cancer risk, including 30 of colon, 13 of breast, 26 of prostate, and 7 of ovarian cancer, and several that assessed the association of vitamin D receptor genotype with cancer risk. The majority of studies found a protective relationship between sufficient vitamin D status and lower risk of cancer. The evidence suggests that efforts to improve vitamin D status, for example by vitamin D supplementation, could reduce cancer incidence and mortality at low cost, with few or no adverse effects.

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Figures

FIGURE 1—
FIGURE 1—
Age-adjusted colon cancer mortality rates, by county area, and contours of annual mean daily solar irradiance in Langleys (calories/cm2), United States, 1970–1994. Source. Developed through use of National Cancer Institute and National Oceanic and Atmospheric Administration data (available at http://www3.cancer.gov/atlasplus/charts.html and http://www.noaa.gov).
FIGURE 2—
FIGURE 2—
Age-adjusted breast cancer mortality rates, by county area, and contours of annual mean daily solar irradiance in Langleys (calories/cm2), United States, 1970–1994. Source. Developed through use of National Cancer Institute and National Oceanic and Atmospheric Administration data (available at http://www3.cancer.gov/atlasplus/charts.html and http://www.noaa.gov).
See this image and copyright information in PMC

References

    1. Utiger R. The need for more vitamin D. N Engl J Med. 1998;338(12): 828–829. - PubMed
    1. Holick MF. Too little vitamin D in premenopausal women: why should we care? Am J Clin Nutr. 2002;76(1):3–4. - PubMed
    1. Compston J. Vitamin D deficiency: time for action. Evidence supports routine supplementation for elderly people and others at risk. BMJ. 1998;317(7171): 1466–1467. - PMC - PubMed
    1. Wharton B. Low plasma vitamin D in Asian toddlers in Britain. BMJ. 1999; 318(7175):2–3. - PMC - PubMed
    1. Garabedian M, Ben-Mehkbi H. Rickets and vitamin D deficiency. In: Holick M, ed. Vitamin D: Molecular Biology, Physiology, and Clinical Applications. Totowa, NJ: Humana; 1999: 273–286.

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