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Review
. 1992 Apr;2(2):249-55.
doi: 10.1016/s0959-437x(05)80281-3.

Myb: a transcriptional activator linking proliferation and differentiation in hematopoietic cells

T Graf  1
Affiliations
Review

Myb: a transcriptional activator linking proliferation and differentiation in hematopoietic cells

T Graf. Curr Opin Genet Dev. 1992 Apr.

Erratum in

  • Curr Opin Genet Dev 1992 Jun;2(3):504

Abstract

Myb is a transcriptional activator protein with repeated helix-turn-helix DNA-binding motifs distantly related to the homeodomain. In hematopoiesis, c-myb appears to control both cell proliferation and differentiation. The mechanisms by which the leukemogenic potential of c-Myb is activated are complex and involve truncations, point mutations, and fusion or coexpression with other proteins.

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