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. 2006 Jan 1;34(Database issue):D140-4.
doi: 10.1093/nar/gkj112.

miRBase: microRNA sequences, targets and gene nomenclature

Sam Griffiths-Jones  1 , Russell J Grocock, Stijn van Dongen, Alex Bateman, Anton J Enright
Affiliations

miRBase: microRNA sequences, targets and gene nomenclature

Sam Griffiths-Jones et al. Nucleic Acids Res. .

Abstract

The miRBase database aims to provide integrated interfaces to comprehensive microRNA sequence data, annotation and predicted gene targets. miRBase takes over functionality from the microRNA Registry and fulfils three main roles: the miRBase Registry acts as an independent arbiter of microRNA gene nomenclature, assigning names prior to publication of novel miRNA sequences. miRBase Sequences is the primary online repository for miRNA sequence data and annotation. miRBase Targets is a comprehensive new database of predicted miRNA target genes. miRBase is available at http://microrna.sanger.ac.uk/.

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Figures

Figure 1
Figure 1
The sequence database entry for hsa-mir-25. The three sections of the page describe the predicted stem–loop hairpin, mature sequences and primary references. The genomic coordinates and contextual information link to the Ensembl database. Each mature miRNA contains an evidence field, and links are provided to predicted target pages.
Figure 2
Figure 2
miRBase Target view page for transcript F13D11.2. The alignment view shows the alignment of miRNA binding sites in orthologous 3′-UTRs. Bits scores, P-values, folding energies and alignments are shown for each miRNA match.
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References

    1. Bartel D.P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116:281–297. - PubMed
    1. Filipowicz W., Jaskiewicz L., Kolb F.A., Pillai R.S. Post-transcriptional gene silencing by siRNAs and miRNAs. Curr. Opin. Struct. Biol. 2005;15:331–341. - PubMed
    1. Sontheimer E.J., Carthew R.W. Silence from within: endogenous siRNAs and miRNAs. Cell. 2005;122:9–12. - PubMed
    1. Ambros V. The functions of animal microRNAs. Nature. 2004;431:350–355. - PubMed
    1. Kidner C.A., Martienssen R.A. The developmental role of microRNA in plants. Curr. Opin. Plant Biol. 2005;8:38–44. - PubMed

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