Review
doi: 10.1196/annals.1339.046.
Regulation of cancer cell survival by Par-4
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- PMID: 16382046
- DOI: 10.1196/annals.1339.046
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Review
Regulation of cancer cell survival by Par-4
Ann N Y Acad Sci.
2005 Nov.
Abstract
Prostate apoptosis response-4 (Par-4) is a unique pro-apoptotic protein that selectively induces apoptosis in cancer cells. Moreover, Par-4 sensitizes cells to the action of diverse apoptotic stimuli and causes tumor regression. This review discusses the prominent structural and functional features of Par-4 and the multiple levels of regulation of its apoptotic function, all of which can be utilized to develop targeted cancer therapy.
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