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Review
. 2006 Jan;103(1):59-76; quiz 77-8.
doi: 10.1007/s00347-005-1296-1.

[Retinoblastoma]

[Article in German]
N Bornfeld  1 , A Schüler, R Bölöni, C Jurklies, R Wieland, W Sauerwein, D Lohmann
Affiliations
Review

[Retinoblastoma]

[Article in German]
N Bornfeld et al. Ophthalmologe. 2006 Jan.

Abstract

Retinoblastomas are the most frequent intraocular tumors in childhood. Untreated, the tumor is almost always fatal. Using a multidisciplinary approach combining the efforts of ophthalmologists, radiation oncologists, pediatric oncologists and geneticists a survival rate of more than 95% can be achieved. Molecular genetic research on the origin of retinoblastomas has substantially helped in our understanding of the origin of malignant tumors in general, as well as to the key role of the Rb-1 gene as a tumor suppressor.

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References

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