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. 2005 Dec;10(3):212-6.
doi: 10.1111/j.1087-0024.2005.10108.x.

Beta-endorphin: the forgotten hair follicle melanotropin

Desmond J Tobin  1 , Söbia Kauser
Affiliations
Free article

Beta-endorphin: the forgotten hair follicle melanotropin

Desmond J Tobin et al. J Investig Dermatol Symp Proc. 2005 Dec.
Free article

Abstract

The proopiomelanocortin (POMC) gene and protein are expressed principally in the pituitary and brain (e.g., hypothalamus). The POMC gene, protein, and derived peptides, however, can also be detected in the skin. It appears that POMC can also be processed in the skin, a tissue that also expresses the prohormone convertases PC1 and PC2 and 7B2 protein. All POMC peptides may be produced in the skin epidermis, dermis, and adnexa by epithelial cells, melanocytes, and mesenchymal cells (e.g., immune cells, fibroblasts, and endothelial cells), and can also be released from cutaneous sensory nerve endings (cf. Slominski et al, 2004).

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