Behavioral symptoms associated with Huntington's disease

Abstract

In addition to the abnormal movements most commonly associated with HD, cognitive impairment and psychiatric symptoms occur in almost all patients. These behavioral symptoms contribute to morbidity and augment what is often an overwhelming caregiver burden. Behavioral interventions may be useful in managing some HD patients with behavioral symptoms, especially irritability and apathy. Patients should be evaluated for underlying medical illness that might contribute to psychiatric symptoms, especially if onset of behavioral change is rapid. According to clinical observation, HD patients with psychiatric symptoms respond to standard pharmacotherapy. Controlled studies are needed to determine the true efficacy of these agents for use in treating people with HD.