[Clinical study of relationship between serum procalcitonin and severity of multiple organ dysfunction syndrome]

Abstract

Objective: To study the correlation between serum procalcitonin (PCT) level and severity of multiple organ dysfunction syndrome (MODS).

Methods: Sixty-one patients with MODS were enrolled in this study. They were divided into infection group and non-infection group. Serum PCT were measured using an immunoluminometric assay. Acute physiology and chronic health evaluation II (APACHE II) scores and Marshall scores of the two groups were recorded and the relationship between PCT levels and APACHE II scores as well as Marshall scores was analysed.

Results: Serum PCT levels in patients with MODS were higher. Serum PCT [13.01(2.73, 64.79) microg/L], APACHE II [(17.50+/-5.35) scores] and Marshall score [(6.38+/-2.46) scores] of infection group were significantly higher than non-infection group [1.50 (0, 2.98) microg/L, (14.67+/-3.01) scores, and (4.62+/-2.01) scores, respectively, P<0.05 or P<0.001]. Serum PCT of infection group and non-infection group did not show correlation with APACHE II (r=0.175, P=0.281; r=0.071, P=0.759). Serum PCT of all patients with MODS showed positive correlation with Marshall score (r=0.514, P<0.001), and correlation index of infection group was higher (r=0.535, P<0.001). Serum PCT of non-infection group did not show correlation with Marshall score (r=0.003, P=0.991).

Conclusion: Serum PCT has clinical values in judgment of the severity of infected patients complicated by MODS.