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Review
. 2006 Feb;18(1):31-9.
doi: 10.1016/j.smim.2005.11.001. Epub 2006 Jan 18.

Pre-BCR signals and the control of Ig gene rearrangements

Jamie K Geier  1 , Mark S Schlissel
Affiliations
Review

Pre-BCR signals and the control of Ig gene rearrangements

Jamie K Geier et al. Semin Immunol. 2006 Feb.

Abstract

Progenitor B lymphocytes that successfully assemble a heavy chain gene encoding an immunoglobulin capable of pairing with surrogate light chain proteins trigger their own further differentiation by signaling via the pre-BCR complex. The pre-BCR signals several rounds of proliferation and, in this expanded population, directs a complex, B cell-specific set of epigenetic changes resulting in allelic exclusion of the heavy chain locus and activation of the light chain loci for V(D)J recombination.

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