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. 2006 Jan;141(1):212-214.
doi: 10.1016/j.ajo.2005.07.078.

Rubella virus is associated with fuchs heterochromic iridocyclitis

Jolanda D F de Groot-Mijnes  1 , Lenneke de Visser, Aniki Rothova, Margje Schuller, Anton M van Loon, Annemarie J L Weersink
Affiliations

Rubella virus is associated with fuchs heterochromic iridocyclitis

Jolanda D F de Groot-Mijnes et al. Am J Ophthalmol. 2006 Jan.

Abstract

Purpose: To determine whether rubella virus (RV) is involved in the pathogenesis of Fuchs heterochromic iridocyclitis (FHI).

Design: Retrospective patient-controlled study.

Methods: Intraocular immunoglobulin G production against RV, herpes simplex virus (HSV), varicella zoster virus (VZV), and Toxoplasma gondii was determined in the aqueous humor of 14 patients with FHI, 13 control subjects with herpetic uveitis anterior, and 19 control subjects with ocular toxoplasmosis by calculation of the Goldmann-Witmer coefficient (GWC).

Results: All patients and control subjects were seropositive for RV. Intraocular antibody production (GWC >3) against RV was found in 13 of 14 patients (93%) with FHI. Intraocular antibody production against HSV, VZV, or T gondii was not detected. None of the control subjects with herpetic uveitis anterior or with toxoplasma chorioretinitis had a positive GWC for rubella virus (P < .0001, Fisher exact test).

Conclusion: Rubella virus, but not HSV, VZV, or T gondii, is associated with FHI.

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