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Comparative Study
. 2006 Apr 3;168(2):345-8.
doi: 10.1016/j.bbr.2005.11.008. Epub 2006 Jan 4.

Mild forced treadmill exercise enhances spatial learning in the aged rat

David S Albeck  1 , Kazuhiro Sano, Gayle E Prewitt, Lori Dalton
Affiliations
Comparative Study

Mild forced treadmill exercise enhances spatial learning in the aged rat

David S Albeck et al. Behav Brain Res. .

Abstract

This study addresses whether or not mild, forced treadmill exercise improves learning and increases neurotrophin levels in the basal forebrain (BF). Neurotrophin deficits in the BF have been implicated in Alzheimer's disease, and physical exercise increases neurotrophins. Aged rats exercised for 7 weeks found the hidden platform faster than controls (F(1, 10)=14.6, p<0.05), and swam shorter pathlengths (F(1, 10)=12.6, p<0.05), with no difference in swim speed. Neurotrophins did not differ.

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