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. 2006 Jan;194(1):199-202.
doi: 10.1016/j.ajog.2005.05.015.

Nevirapine toxicity in a cohort of HIV-1-infected pregnant women

Esau Custódio João  1 , Guilherme A Calvet, Jacqueline A Menezes, Marcos M D'Ippolito, Maria Letícia S Cruz, Luisa Andrea T Salgado, Haroldo J Matos
Affiliations

Nevirapine toxicity in a cohort of HIV-1-infected pregnant women

Esau Custódio João et al. Am J Obstet Gynecol. 2006 Jan.

Abstract

Objective: The purpose of this study was to complete an evaluation of nevirapine (NVP) toxicity in a cohort of HIV+ pregnant women.

Study design: This was a retrospective study of 611 women followed from January 1996 to December 2003. All women who used NVP for > 7 days were included. Multivariate logistic regression was used to test independent association of CD4 and hepatitis C virus (HCV) infection related to the outcome of toxic effects of NVP.

Results: One hundred ninety-seven women were exposed to NVP for > 7 days, and toxicity occurred in 11 (5.6%), leading to drug discontinuation in 7 patients. One case of Stevens-Johnson syndrome occurred. No serious liver toxicity occurred except for 1 grade 4 cholestasis. Median CD4 was 344 in women without toxicities and 298 in women with toxicities. HCV was the only significant factor associated to toxicity by logistic regression (odds ratio [OR] 15.61, P = .001).

Conclusion: NVP toxicities occurred in a very small fraction of patients and were not associated with fatalities.

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