Review
doi: 10.1002/9780470514245.ch6.
Molecular pharmacology of cocaine: a dopamine hypothesis and its implications
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- PMID: 1638923
- DOI: 10.1002/9780470514245.ch6
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Review
Molecular pharmacology of cocaine: a dopamine hypothesis and its implications
Ciba Found Symp.
1992.
Abstract
The reinforcing properties of cocaine have been related to cocaine binding at the dopamine transporter in mesolimbocortical neurons. The molecular properties of the transporter have been studied in a number of laboratories. While this 'dopamine hypothesis' is strongly supported in animal studies of drug self-administration, the extent of its involvement in human drug dependence has not been fully elucidated.
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