Review
doi: 10.1615/critreveukargeneexpr.v15.i3.40.
Increased dosage of the RUNX1/AML1 gene: a third mode of RUNX leukemia?
Affiliations
- PMID: 16390318
- DOI: 10.1615/critreveukargeneexpr.v15.i3.40
Item in Clipboard
Review
Increased dosage of the RUNX1/AML1 gene: a third mode of RUNX leukemia?
Crit Rev Eukaryot Gene Expr.
2005.
Abstract
RUNX1/AML1, located on chromosome 21, is a key factor in the generation and maintenance of hematopoietic stem cells and the gene most frequently implicated in human leukemias. Chromosome translocations and point mutations are well-documented genetic alterations in RUNX leukemia (also known as CBF leukemia). In addition, overdosage or overexpression of RUNX1 is suspected to be a third mode of RUNX1 involvement in leukemogenesis. The possibility that this mode might underlie Down syndrome-related leukemias caused by trisomy of chromosome 21 is discussed.
Similar articles
-
The proto-oncogene ERG in megakaryoblastic leukemias.Cancer Res. 2005 Sep 1;65(17):7596-602. doi: 10.1158/0008-5472.CAN-05-0147. Cancer Res. 2005. PMID: 16140924
-
Increased dosage of Runx1/AML1 acts as a positive modulator of myeloid leukemogenesis in BXH2 mice.Oncogene. 2005 Jun 30;24(28):4477-85. doi: 10.1038/sj.onc.1208675. Oncogene. 2005. PMID: 15856017
-
Physical association of the patient-specific GATA1 mutants with RUNX1 in acute megakaryoblastic leukemia accompanying Down syndrome.Leukemia. 2006 Jun;20(6):1002-8. doi: 10.1038/sj.leu.2404223. Leukemia. 2006. PMID: 16628190
-
Runx1/AML1 in leukemia: disrupted association with diverse protein partners.Leuk Res. 2002 Mar;26(3):221-8. doi: 10.1016/s0145-2126(01)00128-x. Leuk Res. 2002. PMID: 11792409 Review.
-
AML1 interconnected pathways of leukemogenesis.Cancer Invest. 2003;21(1):105-36. doi: 10.1081/cnv-120018821. Cancer Invest. 2003. PMID: 12643014 Review.
Cited by
-
CD74 is a novel transcription regulator.Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):562-567. doi: 10.1073/pnas.1612195114. Epub 2016 Dec 28. Proc Natl Acad Sci U S A. 2017. PMID: 28031488 Free PMC article.
-
Down syndrome: the brain in trisomic mode.Nat Rev Neurosci. 2012 Dec;13(12):844-58. doi: 10.1038/nrn3314. Nat Rev Neurosci. 2012. PMID: 23165261 Review.
-
The use of mouse models for understanding the biology of down syndrome and aging.Curr Gerontol Geriatr Res. 2012;2012:717315. doi: 10.1155/2012/717315. Epub 2012 Feb 23. Curr Gerontol Geriatr Res. 2012. PMID: 22461792 Free PMC article.
-
The RUNX family: developmental regulators in cancer.Nat Rev Cancer. 2015 Feb;15(2):81-95. doi: 10.1038/nrc3877. Epub 2015 Jan 16. Nat Rev Cancer. 2015. PMID: 25592647 Review.
-
Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice.Blood. 2009 Apr 2;113(14):3323-32. doi: 10.1182/blood-2008-06-162248. Epub 2009 Jan 28. Blood. 2009. PMID: 19179305 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
