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Review
. 2005;15(3):217-28.
doi: 10.1615/critreveukargeneexpr.v15.i3.40.

Increased dosage of the RUNX1/AML1 gene: a third mode of RUNX leukemia?

Motomi Osato  1 , Yoshiaki Ito
Affiliations
Review

Increased dosage of the RUNX1/AML1 gene: a third mode of RUNX leukemia?

Motomi Osato et al. Crit Rev Eukaryot Gene Expr. 2005.

Abstract

RUNX1/AML1, located on chromosome 21, is a key factor in the generation and maintenance of hematopoietic stem cells and the gene most frequently implicated in human leukemias. Chromosome translocations and point mutations are well-documented genetic alterations in RUNX leukemia (also known as CBF leukemia). In addition, overdosage or overexpression of RUNX1 is suspected to be a third mode of RUNX1 involvement in leukemogenesis. The possibility that this mode might underlie Down syndrome-related leukemias caused by trisomy of chromosome 21 is discussed.

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