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. 2006 Jan;44(1):47-50.
doi: 10.1128/JCM.44.1.47-50.2006.

Positive correlation between Epstein-Barr virus viral load and anti-viral capsid immunoglobulin G titers determined for Hodgkin's lymphoma patients and their relatives

Caroline Besson  1 , Corinne Amiel, Catherine Le-Pendeven, Pauline Brice, Christophe Fermé, Patrice Carde, Olivier Hermine, Martine Raphael, Laurent Abel, Jean-Claude Nicolas
Affiliations

Positive correlation between Epstein-Barr virus viral load and anti-viral capsid immunoglobulin G titers determined for Hodgkin's lymphoma patients and their relatives

Caroline Besson et al. J Clin Microbiol. 2006 Jan.

Abstract

Markers of Epstein-Barr virus (EBV) infection include measures of specific serological titers and of viral load (VLo) in peripheral blood mononuclear cells. Few studies have investigated the correlation between these two phenotypes. Here, we found that there was no correlation between VLo and either anti-EBV nuclear antigen type 1 or anti-early antigen immunoglobulin G (IgG) titer but that anti-viral capsid antigen (VCA) IgG titer increased with VLo in peripheral blood mononuclear cells in patients with Hodgkin's lymphoma (P = 3.10(-3)). A similar pattern was observed in healthy first-degree relatives (parents and siblings) of patients (P = 6.10(-4)). Our results indicate that anti-VCA IgG titers and EBV VLo are specifically correlated EBV phenotypes.

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Figures

FIG. 1.
FIG. 1.
Anti-VCA titers distributions according to VLo ordinal classes. Mean titers with standard SEMs are shown for each ordinal class of VLo for patients (squares, full lines) and their relatives (diamonds, dotted lines). Sample sizes for each VLo class are presented in the bottom line.
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