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Comparative Study
. 1975 Apr;15(4):1029-32.
doi: 10.1128/JVI.15.4.1029-1032.1975.

Mosquito cells infected with vesicular stomatitis virus yield unsialylated virions of low infectivity

R H Schloemer, R R Wagner
Comparative Study

Mosquito cells infected with vesicular stomatitis virus yield unsialylated virions of low infectivity

R H Schloemer et al. J Virol. 1975 Apr.

Abstract

Vesicular stomatitis virus propagated in and released from Aedes albopictus cells had the normal complement of viral proteins; the glycoprotein contained carbohydrate but no sialic acid. These virions had markedly reduced hemagglutinating activity and exhibited a very high ratio of physical particles to infectious virus. In vitro sialylation of vesicular stomatitis virions grown in mosquito cells resulted in a 100-fold increase in both infectivity and hemagglutination titers to levels approaching those of virus grown in BHK-21 cells. These experiments provide an example of host-controlled modification of viral infectivity.

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