Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006;21(3):144-7.
doi: 10.1159/000090674. Epub 2006 Jan 2.

Neuropathologic correlates of apathy in Alzheimer's disease

Gad A Marshall  1 , Lynn A Fairbanks, Sibel Tekin, Harry V Vinters, Jeffrey L Cummings
Affiliations

Neuropathologic correlates of apathy in Alzheimer's disease

Gad A Marshall et al. Dement Geriatr Cogn Disord. 2006.

Abstract

Apathy is the most commonly observed behavioral disturbance in Alzheimer's disease (AD) and has been suggested to be frontally mediated. Neuritic plaque (NP) and neurofibrillary tangle (NFT) counts were performed for 8 brain regions in 29 subjects with definite AD. Neuropsychiatric Inventory (NPI) for autopsied subjects was obtained from questioning of caregivers of subjects included in the study. Chronic apathy and total NPI composite scores correlated with anterior cingulate NFT counts (r = 0.518, p = 0.01, and r = 0.438, p = 0.032). This analysis suggests that chronic apathy in AD correlates with a greater anterior cingulate NFT burden and that chronic behavioral changes are more reflective than acute changes of disease pathology.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources