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. 2006 Jan;7(1):31-5.
doi: 10.1038/sj.embor.7400616.

RNA exodus to Israel: RNA controlling function in the far reaches of the neuron. Workshop on RNA control on neuronal function

Gary J Bassell  1 , Jeffery L Twiss
Affiliations

RNA exodus to Israel: RNA controlling function in the far reaches of the neuron. Workshop on RNA control on neuronal function

Gary J Bassell et al. EMBO Rep. 2006 Jan.

Abstract

Workshop on RNA Control of Neuronal Function

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Figures

Figure 1
Figure 1
Regulation of neuronal functions by localized mRNAs. Schematic of a polarized neuron. For dendrites, translationally active mRNAs (polysomes) are concentrated at the base of the dendritic spines. Post-synaptic protein synthesis is regulated by trans-synaptic stimuli where the locally synthesized proteins contribute to synaptic components of the dendritic spine, translational machinery and cytoskeleton. Activity also selectively targets some dendritic mRNAs (for example, Arc) to activated synapses. For axons, ribosomes appear uniquely concentrated in growth cones. Axonal protein synthesis is regulated by guidance cues in growing axons and by injury in mature axons. Guidance cues also modulate anterograde transport of axonal mRNAs. In addition to synthesis of cytoskeletal elements, axonally synthesized importin-β and vimentin proteins assemble into a retrograde signalling complex with existing axonal proteins.
None
The EMBO Workshop on RNA Control of Neuronal Function took place in Kfar Blum, Israel, between 22 and 26 May 2005, and was organized by J. Richter, R. Singer and J. Yisraeli. More information about the meeting can be found at: www.embo-rna-neurons.com
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