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Case Reports
. 2005 Oct;40(5):585-92.
doi: 10.1016/S0008-4182(05)80050-X.

Primary intraocular lymphoma arising during methotrexate treatment of temporal arteritis

Kamilia Rizkalla  1 , Sylvia Rodrigues, Alain Proulx, David P Tingey, J Godfrey Heathcote
Affiliations
Case Reports

Primary intraocular lymphoma arising during methotrexate treatment of temporal arteritis

Kamilia Rizkalla et al. Can J Ophthalmol. 2005 Oct.

Abstract

Case report: Primary intraocular lymphoma arose over a period of 9 months in the left eye of an 81-year-old woman who was blind in both eyes from temporal arteritis. During this period, she was treated with prednisone and methotrexate. Following a sudden total hyphema, the eye was enucleated. Examination revealed that, in addition to iris neovascularisation and central retinal artery occlusion, the neurosensory retina was replaced by atypical lymphocytes.

Comments: Histological and immunohistochemical studies confirmed the presence of a lymphoma with features indicative of an immunosuppression-related disorder. The relationship of the lymphoma to the vascular changes within the eye is discussed.

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