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Comparative Study
. 2005 Dec;28(12):1324-7.
doi: 10.1007/BF02977895.

Monoamine oxidase inhibitory constituents from the fruits of Cudrania tricuspidata

Xiang Hua Han  1 , Seong Su Hong, Ji Sang Hwang, Seon Hwa Jeong, Ji Hye Hwang, Min Hee Lee, Myung Koo Lee, Dongho Lee, Jai Seup Ro, Bang Yeon Hwang
Affiliations
Comparative Study

Monoamine oxidase inhibitory constituents from the fruits of Cudrania tricuspidata

Xiang Hua Han et al. Arch Pharm Res. 2005 Dec.

Abstract

A methylene chloride soluble fraction of the fruits of Cudrania tricuspidata significantly inhibited the mouse brain monoamine oxidase (MAO). Three known prenylated isoflavones were isolated and identified by activity-guided fractionation. Gancaonin A (1), 4'-O-methylalpinumisoflavone (2), and alpinumisoflavone (3) inhibited MAO activity in a concentration-dependent manner with IC50 values of 19.4, 23.9, and 25.8 microM, respectively. Of these, gancaonin A (1) showed a selective and potent inhibitory effect against MAO-B (IC50 0.8 microM) than MAO-A (IC50 >800 microM). The kinetic analysis using Lineweaver-Burk plots indicated that gancaonin A (1) competitively inhibited MAO-B.

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