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. 2005 Dec;42(10):823-7.
doi: 10.1080/02770900500369868.

Symptom control and improved functioning: the effect of omalizumab on asthma-related quality of life (ARQL)

Allan T Luskin  1 , Mark Kosinski, Brian W Bresnahan, Mark Ashby, Dennis A Wong
Affiliations

Symptom control and improved functioning: the effect of omalizumab on asthma-related quality of life (ARQL)

Allan T Luskin et al. J Asthma. 2005 Dec.

Abstract

This investigation evaluated variability in asthma-related quality-of-life (ARQL) outcomes among patients randomized to omalizumab or placebo. Pooled data on the Asthma Quality of Life Questionnaire (AQLQ) from two trials were used (n = 948). Variability in ARQL outcomes was determined by categorizing AQLQ score changes according to minimal clinically important difference (MCID: 0.5 points) and large clinically important difference (LCID: 1.5 points) score changes. A greater proportion of patients achieved improvement in every domain of AQLQ scores during all periods with omalizumab compared with placebo. Omalizumab-treated patients showed greater clinically important improvement in ARQL compared with patients receiving placebo.

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